168MO GeparX: Denosumab (Dmab) as add-on to different regimen of nab-paclitaxel (nP)-anthracycline based neoadjuvant chemotherapy (NACT) in early breast cancer (BC): Subgroup analyses by RANK expression and HR status
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چکیده
منابع مشابه
Weekly paclitaxel plus carboplatin is an effective nonanthracycline-containing regimen as neoadjuvant chemotherapy for breast cancer.
BACKGROUND To evaluate the activity and safety of nonanthracycline-containing weekly PCb [paclitaxel (Taxol) plus carboplatin] regimen in neoadjuvant treatment of breast cancer. PATIENTS AND METHODS Eligible patients were assigned to receive four cycles of PCb with dose of paclitaxel 80 mg/m(2) and carboplatin at an area under the curve of 2 mg x min/ml, given day 1, day 8 and day 15 of every...
متن کاملClinical and Pathological Response to Neoadjuvant Anthracycline Based Chemotherapy in women with breast cancer
Background Neoadjuvant chemotherapy has been used as a primary treatment for locally advanced or inflammatory breast cancer, and recently extended to operable breast cancer. The aim of this study was to evaluate the predictive value of different histologic factors in breast cancer treated with neoadjuvant anthracycline chemotherapy in Tunisian women. Methods A total of 109 stage II and III br...
متن کاملPrognostic value of Ki67 expression in HR-negative breast cancer before and after neoadjuvant chemotherapy.
BACKGROUND Immunohistochemical (IHC) expression of Ki67 has been identified as a prognostic and predictive marker in hormone receptor (HR)-positive breast cancer, however, there is little evidence of the association of Ki67 with prognosis in HR-negative patients. We aimed to assess the benefit of Ki67 assessment in HR-negative breast cancers after neoadjuvant chemotherapy (NAC). METHODS In th...
متن کاملNeoadjuvant capecitabine and docetaxel (plus trastuzumab): an effective non-anthracycline-based chemotherapy regimen for patients with locally advanced breast cancer.
BACKGROUND To evaluate capecitabine-docetaxel (XT), with trastuzumab (H) in human epidermal growth factor receptor 2 (HER2)-positive disease, in inoperable locally advanced breast cancer (LABC). PATIENTS AND METHODS Patients received up to six neoadjuvant 21-day cycles of capecitabine 900 mg/m(2) twice daily, days 1-14, plus docetaxel 36 mg/m(2), days 1 and 8. Patients with HER2-positive dise...
متن کاملTaxane and Anthracycline Based Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer in India
Breast cancer is the most common cancer among females in India, as per urban cancer registries. The Annual Age Adjusted Rate (AAR) varies from 30 per 100,000 in Mumbai to 33.4 per 100,000 in Delhi (Manoharan et al., 2010). LABC refers to large breast tumors (>5 cm) associated with either skin/ chest wall involvement or with fixed axillary lymph nodes or spread to ipsilateral internal mammary or...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2020
ISSN: 0923-7534
DOI: 10.1016/j.annonc.2020.08.290